David Salat
Ph.D. Graduate (2000)
Undergraduate Degree
B.A. (Psychology, 1995), Rutgers University
Training at OHSU
1995-2000
Second Year Project
(1997) Does white matter matter? (Mentor: Jeri S. Janowsky, Ph.D.)
Ph.D. Dissertation
(2000) Selective neural and cognitive alterations in the prefrontal cortex with healthy aging and Alzheimer's disease (Mentor: Jeri S. Janowsky, Ph.D.)
Current position
Assistant Professor in Radiology at Harvard Medical School
Assistant Neuroscientist at Massachusetts General Hospital Department of Radiology, MGH
Director, Neuroimaging Research for Veterans Center, Boston VA Healthcare System
Background & Interests
My dissertation research in Behavioral Neuroscience at OHSU examined degenerative changes in the prefrontal cortex with healthy aging and Alzheimer's disease (AD) using structural magnetic resonance imaging techniques in human participants. This work was performed in the laboratory of Dr. Jeri Janowsky and in collaboration with Dr. Jeffrey Kaye in the Department of Neurology. I am currently an Assistant Professor in the Massachusetts General Hospital Department of Radiology/Martinos Center for Biomedical Imaging following up my dissertation and postdoctoral research examining neural and cognitive degeneration in the brain with aging and AD. Information about my current work can be found here. Ongoing work focuses on how cerebrovascular risk contributes to brain tissue degeneration and the development of dementia.
Publications
Chen JJ, Rosas HD, Salat DH. Age-associated reductions in cerebral blood flow are independent from regional atrophy. Neuroimage. 2011 Mar 15;55(2):468-78. PMID: 21167947
Leritz EC, Salat DH, Williams VJ, Schnyer DM, Rudolph JL, Lipsitz L, Fischl B, McGlinchey RE, Milberg WP. Thickness of the human cerebral cortex is associated with metrics of cerebrovascular health in a normative sample of community dwelling older adults. Neuroimage. 2011 Feb 14;54(4):2659-71. Epub 2010 Oct 28. PMID: 21035552
Salat DH, Chen JJ, van der Kouwe AJ, Greve DN, Fischl B, Rosas HD. Hippocampal degeneration is associated with temporal and limbic gray matter/white matter tissue contrast in Alzheimer's disease. Neuroimage. 2011 Feb 1;54(3):1795-802. Epub 2010 Oct 18. PMID: 20965261
Bechtel N, Scahill RI, Rosas HD, Acharya T, van den Bogaard SJ, Jauffret C, Say MJ, Sturrock A, Johnson H, Onorato CE, Salat DH, Durr A, Leavitt BR, Roos RA, Landwehrmeyer GB, Langbehn DR, Stout JC, Tabrizi SJ, Reilmann R. Tapping linked to function and structure in premanifest and symptomatic Huntington disease. Neurology. 2010 Dec 14;75(24):2150-60. Epub 2010 Nov 10. PMID: 21068430
Desikan RS, Sabuncu MR, Schmansky NJ, Reuter M, Cabral HJ, Hess CP, Weiner MW, Biffi A, Anderson CD, Rosand J, Salat DH, Kemper TL, Dale AM, Sperling RA, Fischl B; Alzheimer's Disease Neuroimaging Initiative. Selective disruption of the cerebral neocortex in Alzheimer's disease. PLoS One. 2010 Sep 23;5(9):e12853. PMID: 20886094.
Dierksen GA, Skehan ME, Khan MA, Jeng J, Nandigam RN, Becker JA, Kumar A, Neal KL, Betensky RA, Frosch MP, Rosand J, Johnson KA, Viswanathan A, Salat DH, Greenberg SM. Spatial relation between microbleeds and amyloid deposits in amyloid angiopathy. Ann Neurol. 2010 Oct;68(4):545-8. PMID: 20865701.
Desikan RS, Cabral HJ, Settecase F, Hess CP, Dillon WP, Glastonbury CM, Weiner MW, Schmansky NJ, Salat DH, Fischl B; Alzheimer's Disease Neuroimaging Initiative. Automated MRI measures predict progression to Alzheimer's disease. Neurobiol Aging. 2010 Aug;31(8):1364-74. Epub 2010 Jun 8. PMID: 20570399
Leritz EC, Salat DH, Milberg WP, Williams VJ, Chapman CE, Grande LJ, Rudolph JL, Schnyer DM, Barber CE, Lipsitz LA, McGlinchey RE. Variation in blood pressure is associated with white matter microstructure but not cognition in African Americans. Neuropsychology. 2010 Mar;24(2):199-208. PMID: 20230114
Rosas HD, Lee SY, Bender AC, Zaleta AK, Vangel M, Yu P, Fischl B, Pappu V, Onorato C, Cha JH, Salat DH, Hersch SM. Altered white matter microstructure in the corpus callosum in Huntington's disease: implications for cortical "disconnection". Neuroimage. 2010 Feb 15;49(4):2995-3004. Epub 2009 Oct 19. PMID: 19850138
Knake S, Salat DH, Halgren E, Halko MA, Greve DN, Grant PE. Changes in white matter microstructure in patients with TLE and hippocampal sclerosis. Epileptic Disord. 2009 Sep;11(3):244-50. Epub 2009 Sep 7. PMID: 19736169
Salat DH, Kaye JA, Janowsky JS. Greater orbital prefrontal volume selectively predicts worse working memory performance in older adults. Cereb Cortex. 2002 May;12(5):494-505.
Rosas HD, Liu AK, Hersch S, Glessner M, Ferrante RJ, Salat DH, van der Kouwe A, Jenkins BG, Dale AM, Fischl B. Regional and progressive thinning of the cortical ribbon in Huntington's disease. Neurology. 2002 Mar 12;58(5):695-701.
Fischl B, Salat DH, Busa E, Albert M, Dieterich M, Haselgrove C, van der Kouwe A, Killiany R, Kennedy D, Klaveness S, Montillo A, Makris N, Rosen B, Dale AM. Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain. Neuron. 2002 Jan 31;33(3):341-55.
Salat DH, Kaye JA, Janowsky JS. Selective preservation and degeneration within the prefrontal cortex in aging and Alzheimer disease. Arch Neurol. 2001 Sep;58(9):1403-8.
Salat DH, Stangl PA, Kaye JA, Janowsky JS. Sex differences in prefrontal volume with aging and Alzheimer's disease. Neurobiol Aging. 1999 Nov-Dec;20(6):591-6.
Salat DH, Kaye JA, Janowsky JS. Prefrontal gray and white matter volumes in healthy aging and Alzheimer disease. Arch Neurol. 1999 Mar;56(3):338-44.
Salat D, Ward A, Kaye JA, Janowsky JS. Sex differences in the corpus callosum with aging. Neurobiol Aging. 1997 Mar-Apr;18(2):191-7.
Dougherty KD, Salat D, Walsh TJ. Intraseptal injection of the cholinergic immunotoxin 192-IgG saporin fails to disrupt latent inhibition in a conditioned taste aversion paradigm. Brain Res. 1996 Oct 14;736(1-2):260-9.