PubMed Search

Microbial colonization activates an immune fight-and-flight response via neuroendocrine signaling.
Aballay, A. and Singh. J. (2019).  Dev. Cell. April 8, (49) 1–11. Read via ScienceDirect.

Non-proteolytic activity of 19S proteasome subunit RPT-6 regulates GATA transcription during response to infection.
Olaitan, A.O. and Aballay, A. (2018). PLOS Genetics. Sep 28;14(9):e1007693. doi: 10.1371/journal.pgen.1007693.

Distinct Roles of Sensory Neurons in Mediating Pathogen Avoidance and Neuropeptide-Dependent Immune Regulation.
Cao X, Kajino-Sakamoto R, Doss A, Aballay A. Cell Rep. 2017 Nov 7;21(6):1442-1451. doi: 10.1016/j.celrep.2017.10.050. PMID: 29117551

Endoplasmic Reticulum Stress Caused by Lipoprotein Accumulation Suppresses Immunity against Bacterial Pathogens and Contributes to Immunosenescence.
Singh J, Aballay A. MBio. 2017 May 30;8(3). pii: e00778-17. doi: 10.1128/mBio.00778-17. PMID: 28559483 

Effects of methyl and inorganic mercury exposure on genome homeostasis and mitochondrial function in Caenorhabditis elegans.
Wyatt LH, Luz AL, Cao X, Maurer LL, Blawas AM, Aballay A, Pan WK, Meyer JN. DNA Repair (Amst). 2017 Apr;52:31-48. doi: 10.1016/j.dnarep.2017.02.005. Epub 2017 Feb 13. PMID: 28242054

Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington's disease.
Gomez-Pastor R, Burchfiel ET, Neef DW, Jaeger AM, Cabiscol E, McKinstry SU, Doss A, Aballay A, Lo DC, Akimov SS, Ross CA, Eroglu C, Thiele DJ. Nat Commun. 2017 Feb 13;8:14405. doi: 10.1038/ncomms14405. PMID: 28194040 

Natural Genetic Variation in the Caenorhabditis elegans Response to Pseudomonas aeruginosa.
Martin N, Singh J, Aballay A. G3 (Bethesda). 2017 Apr 3;7(4):1137-1147. doi: 10.1534/g3.117.039057. PMID: 28179390 

Neural Inhibition of Dopaminergic Signaling Enhances Immunity in a Cell-Non-autonomous Manner.
Cao, X. and Aballay, A. (2016). Curr Biol. Aug 9. pii: S0960-9822(16)30675-3. doi: 10.1016/j.cub.2016.06.036. [Epub ahead of print] 

Genetic screen reveals link between the maternal-effect sterile gene mes-1 and P. aeruginosa-induced neurodegeneration in C. elegans.
Wu, Q., Cao, X., Yan, D., Wang, D., and Aballay, A. (2015). J Biol Chem. Oct 16. pii: jbc.M115.674259 

Cellular Responses to Infections in Caenorhabditis elegans.
Sun J., Aballay A., and Singh V. (2015). Encyclopedia of Cell Biology, Vol 2, Waltham, MA: Academic Press, 2016, pp. 845-852. doi:10.1016/B978-0-12-394447-4.20074-6. 

Recovery from an acute infection in C. elegans requires the GATA transcription factor ELT-2.
Head, B. and Aballay, A. (2014). PLOS Genetics, Oct 23. doi:10.1371/journal.pgen.1004609.

Whole-animal chemical screen identifies colistin as a new immunomodulator that targets conserved pathways.
Cai, Y., Cao, X., Aballay A. (2014). mBio, Aug 12;5(4). pii: e01235-14. doi: 10.1128/mBio.01235-14.

Role of the nervous system in the control of proteostasis during innate immune activation: Insights from C. elegans.
Aballay, A. (2013). PLoS Pathog, Aug 9(8): e1003433. 

Organismal regulation of XBP-1-mediated unfolded protein response during development and immune activation.
Sun J., Liu Y, Aballay A. (2012). EMBO Rep, Aug 31;13(9):855-60. Epub 2012 Jul 13. Review

ER stress pathway required for immune homeostasis is neurally controlled by arrestin-1.
Singh, V. and Aballay, A. (2012). J Biol Chem, Epub ahead of print Aug 8. 

Neuronal GPCR controls innate immunity by regulating non-canonical unfolded protein response genes.
Sun, J., Singh, V., Kajino-Sakamoto, R., and Aballay, A. (2011). Science, Epub 2011 April 7. Review.

Models to study ancient host-pathogen interactions: lessons from Crete.
Means, T.K. and Aballay, A. (2011). EMBO Rep, 12(1):5-7. 

A conserved PMK-1/p38 MAPK is required in Caenorhabditis elegans tissue-specific immune response to Yersinia pestis infection.
Bolz, D.D., Tenor, J.L., and Aballay, A. (2010). J Biol Chem, 285:10832-10840. 

Regulation of DAF-16-mediated innate immunity in Caenorhabditis elegans.
Singh, V. and Aballay, A. (2009). J Biol Chem, 284:35580-35587.

Nucleolar proteins suppress C. elegans innate immunity by inhibiting p53/CEP-1.
Fuhrman, L.E., Kumar Goel, A., Smith, J., Shianna, K.V., Aballay, A. (2009). PLoS Genetics, 5: e1000657. doi:10.1371/journal.pgen.1000657.  

Innate immunity in Caenorhabditis elegans is regulated by neurons expressing NPR-1/GPCR.
Styer, K.L., Singh, V., Macosko, E., Steele, S.E., Bargmann, C.I., and Aballay, A. (2008). Science, 17:460-464. 
Podcast. Review. 

Unfolded protein response genes regulated by CED-1 are required for Caenorhabditis elegans innate immunity.
Haskins, K.A., Russell, J.F., Gaddis, N., Dressman, H.K., and Aballay, A. (2008). Dev Cell, 15:87-97. Review.

A conserved Toll-like receptor is required for Caenorhabditis elegans innate immunity.
Tenor, J.L., and Aballay, A. (2008). EMBO Reports, 9:103-109. 

High-throughput isolation and mapping of C. elegans mutants susceptible to pathogen infection.
Fuhrman, L.E., Shianna, K.V., Aballay, A. (2008). PLoS One, 6:e2882.

Study of the role of CCR5 in a mouse model of intranasal challenge with Y. pestis.
Styer, K.L., Click, E.M., Hopkins, G.W., Frothingham, R., and Aballay, A. (2007). Microbes and Infection, 9:1135-1138.

A heat-shock factor HSF-1 response pathway is important for Caenorhabditis elegans immunity against Pseudomonas aeruginosa.
Singh, V. and Aballay, A. (2006). Proc Natl Acad Sci USA, 103:13092-13097. 

Heat shock and genetic activation of HSF-1 enhance immunity to bacteria.
Singh, V. and Aballay, A. (2006). Cell Cycle, 5:2443-2446. 

The Caenorhabditis elegans ABL-1 tyrosine kinase is required for Shigella flexneri pathogenesis.
Burton, E.A., Pendergast, A.M., and Aballay, A. (2006). Appl Environ Microbiol, 72:5043-51. 

GATA transcription factor required for immunity to bacterial and fungal pathogens.
Kerry, S., TeKippe, M., Gaddis, N.C., and Aballay, A. (2006). Plos ONE, 1:e77. 

Yersinia pestis kills Caenorhabditis elegans by a biofilm-independent process that involves novel virulence factors.
Styer, K.L., Hopkins, G.W., Plano, G.V., Frothingham, R., and Aballay, A. (2005). EMBO Reports, 6:992-997.  

Worms and flies as alternative genetically tractable animal models to study host-pathogen interactions.
Mylonakis, E. and Aballay, A. (2005). Infect Immun, 73:3833-3841. 

Caenorhabditis elegans-based screen identifies Salmonella virulence factors required for conserved host-pathogen interactions.
Tenor, J.L., McCormick, B.A., Ausubel, F.M., Aballay, A. (2004). Curr Biol, 14:1018-1024. 

Caenorhabditis elegans innate immune response triggered by Salmonella enterica requires intact LPS and is mediated by a MAPK signaling pathway.
Aballay, A., Drenkard, E., Hilbun, L.R., Ausubel, F.M. (2003). Curr Biol, 13:47-52. 

Caenorhabditis elegans model system for study of host pathogen interactions.
Aballay, A and Ausubel, F.M. (2002). Curr Opin Microbiol, 5:97-101. 

Programmed cell death mediated by ced-3 and ced-4 protects Caenorhabditis elegans from Salmonella typhimurium-mediated killing.
Aballay, A. and Ausubel, F.M. (2001). Proc Natl Acad Sci USA, 98:2735-2739. 

Salmonella typhimurium proliferates and establishes a persistent infection in the intestine of Caenorhabditis elegans.
Aballay, A., Yorgey, P., Ausubel, M.A. (2000). Curr Biol, 30:1539-1542. 

Intracellular transport of Brucella abortus in J774 macrophages.
Arenas, N.A., Staskevich, A.S., Aballay, A., and Mayorga, L.S. (2000). Infect Immun, 68:4255-4263.