Christopher Corless, MD, PhD

Professor

Vice Chair, Research

Chief Medical Officer, Knight Diagnostic Laboratories

Clinical Services

Molecular Pathology

Education

PhD (Molecular Biology) Washington University, 1988

MD, Washington University, 1988

AB, University of California, 1981

Training

Residency in Anatomic Pathology with specialty training in Gastrointestinal Pathology, Brigham and Women's Hospital, 1988-1992

Fellowship in Gentourinary Pathology, Brigham and Womens Hospital, 1992-1993

Board Certifications

Anatomic Pathology, 1993

Interests

Role of oncogenic mutations in GI stromal tumors, melanomas, and other solid tumors. Development and application of new molecular diagnostic assays for use in research and clinical trials. Further information can be found on the Corless research page.

Publications

Gay ND, Wang Y, Beadling C, Warrick A, Neff T, Corless CL, Tolba K, "Durable Response to Afatinib in Lung Adenocarcinoma Harboring NRG1 Gene Fusions", J Thorac Oncol 2017 May 10. pii: S1556-0864(17)30359-3. [Epub ahead of print] PMID: 28502724

Heinrich MC, Corless CL, Demetri GD, "Defining the Impact of Adjuvant Therapy in Molecularly Defined Subsets of Gastrointestinal Stromal Tumor: From Lumping to Splitting", J Mol Diagn 2017 May;19(3):341-365. PMID: 28334361

Jennings LJ, Arcila ME, Corless C, Kamel-Reid S, Lubin IM, Pfeifer J, Temple-Smolkin RL, Voelkerding KV, Nikiforova MN, "Guidelines for Validation of Next-Generation Sequencing-Based Oncology Panels: A Joint Consensus Recommendation of the Association for Molecular Pathology and College of American Pathologists", J Mol Diagn 2017 Mar 21; PMID: 28341590

Corless CL, "Next-Generation Sequencing in Cancer Diagnostics", J Mol Diagn 2016 Nov;18(6):813-816. PMID: 27664753Bergstrom CP, Geest K, O'Gara R, Corless CL, Morgan TK, "Discordant Mutations in Paired Primary and Metastatic Endometrial Adenocarcinomas Identified by Semiconductor-Based Sequencing for Rapid Cancer Genotyping," Reprod Sci 2016 May 11 [Epub ahead of print]. PMID: 27170661.

Beadling C, Wald AI, Warrick A, Neff TL, Zhong S, Nikiforov YE, Corless CL, Nikiforova MN, "A Multiplexed Amplicon Approach for Detecting Gene Fusions by Next-Generation Sequencing," J Mol Diagn 2016 Mar; 18(2):165-75. PMID: 26747586.

Patil DT, Ma S, Konishi M, Carver PD, Pukay M, Beadling C, Corless CL, Rubin BP, "Utility of BRAF V600E Mutation-Specific Immunohistochemistry in Detecting BRAF V600E-Mutated Gastrointestinal Stromal Tumors," Am J Clin Pathol 2015 Nov; 144(5):782-9. PMID: 26486743.

Blanke CD, Rankin C, Corless C, Eary JF, Mulder K, Okuno SH, George S, Heinrich M, "S0502: A SWOG Phase III Randomized Study of Imatinib, With or Without Bevacizumab, in Patients With Untreated Metastatic or Unresectable Gastrointestinal Stromal Tumors," Oncologist 2015 Nov 17 [Epub ahead of print]. PMID: 26576593.

Butler TM, Johnson-Camacho K, Peto M, Wang NJ, Macey TA, Korkola JE, Koppie TM, Corless CL, Gray JW, Spellman PT, "Exome Sequencing of Cell-Free DNA from Metastatic Cancer Patients Identifies Clinically Actionable Mutations Distinct from Primary Disease," PLoS One 2015 Aug 28; 10(8):e0136407. PMID: 26317216.

Ben-Josef E, Guthrie KA, El-Khoueiry AB, Corless CL, Zalupski MM, Lowy AM, Thomas CR Jr, Alberts SR, Dawson LA, Micetich KC, Thomas MB, Siegel AB, Blanke CD, "SWOG S0809: A Phase II Intergroup Trial of Adjuvant Capecitabine and Gemcitabine Followed by Radiotherapy and Concurrent Capecitabine in Extrahepatic Cholangiocarcinoma and Gallbladder Carcinoma," J Clin Oncol 2015 Aug 20; 33(24):2617-22. PMID: 25964250.

Carvajal RD, Lawrence DP, Weber J, Gajewski TF, Gonzalez R, Lutzky J, O'Day SJ, Hamid O, Wolchok JD, Chapman PB, Sullivan RJ, Teitcher JB, Ramaiya NH, Giobbie-Hurder A, Antonescu CR, Heinrich MC, Bastian B, Corless CL, Fletcher JA, Hodi FS, "Phase II Study of Nilotinib in Melanoma Harboring KIT Alterations Following Progression to Prior KIT Inhibition," Clin Cancer Res 2015 May 15; 21(10):2289-96. PMID: 25695690.

Lopez-Chavez A, Thomas A, Rajan A, Raffeld M, Morrow B, Kelly R, Carter CA, Guha U, Killian K, Lau CC, Abdullaev Z, Xi L, Pack S, Meltzer PS, Corless CL, Sandler A, Beadling C, Warrick A, Lieweher DF, Steinberg SM, Berman A, Doyle A, Szabo E, Wang Y, Giaccone G, "Molecular Profiling and Targeted Therapy for Advanced Thoracic Malignancies: a biomarker derived multi-arm, multi-histology phase II 'basket' trial," J Clin Oncol 2015 Mar 20;33(9):1000-7. PMID: 25667274.

Grasso C, Butler T, Rhodes K, Quist M, Neff TL, Moore S, Tomlins SA, Reinig E, Beadling C, Andersen M, Corless CL, "Assessing copy number alterations in targeted, amplicon-based next-generation sequencing data," J Mol Diagn 2015 Jan; 17(1):53-63. PMID: 25468433.

Javidi-Sharifi N, Traer E, Martinez J, Gupta A, Taguchi T, Dunlap J, Heinrich MC, Corless CL, Rubin BP, Druker BJ, Tyner JW, "Crosstalk between KIT and FGFR3 Promotes Gastrointestinal Stromal Tumor Cell Growth and Drug Resistance," Cancer Res 2015 Mar 1; 75(5):880-91. PMID: 25432174.

Nannini M, Astolfi A, Urbini M, Indio V, Santini D, Heinrich MC, Corless CL, Ceccarelli C, Saponara M, Mandrioli A, Lolli C, Ercolani G, Brandi G, Biasco G,Pantaleo MA, "Integrated genomic study of quadruple-WT GIST (KIT/PDGFRA/SDH/RAS pathway wild-type GIST) (quadrupleWT, or KITWT/PDGFRAWT/ SDHWT/RAS-PWT GIST)," BMC Cancer 2014 Sep 20; 14(1):685. PMID: 25239601.