Matthew Wood, M.D., Ph.D.

Assistant Professor

Neuropathologist

Education

MD, Geisel School of Medicine at Dartmouth, 2012
PhD, Dartmouth Medical School, 2010

BS, Carnegie Mellon University, 2002

Training

Neuropathology Fellow, University of California San Francisco, 2014-2016

Pathology Resident, University of California San Francisco, 2012-2014

Board Certifications

Anatomic Pathology (ABP), 2016

Neuropathology (ABP), 2016

Interests

Matthew Wood earned his MD and a PhD in pharmacology and toxicology at Dartmouth Medical School in Hanover, New Hampshire. His graduate work with Dr. Yolanda Sanchez involved modeling the genetic defect of neurofibromatosis type 1 in budding yeast in order to create a novel drug screening platform. He then completed his residency in anatomic pathology and neuropathology fellowship at University of California, San Francisco, where he developed an interest in the molecular classification of brain tumors. He continued as a postdoctoral research fellow at the UCSF Brain Tumor Research Center, working with Dr. Russ Pieper, as part of an NIH-funded training program in translational brain tumor research.

Dr. Wood's clinical interests are in diagnostic surgical and autopsy neuropathology, and using molecular testing to characterize brain tumors to enable the best possible disease classification, prognostication, and treatment.

Publications

Wood MD, Tihan T, Perry AJ, Chacko G, Turner C, Pu C, Payne C, Yu A, Bannykh S, Solomon DA. "Multimodal molecular analysis of astroblastoma enables reclassification of most cases into more specific molecular entities." Brain Pathol. 2017 Sep 28. PMID: 28960623.

Wood MD, Reis GF, Reuss DE, Phillips JJ. "Protein Analysis of Glioblastoma Primary and Posttreatment Pairs Suggests a Mesenchymal Shift at Recurrence." J Neuropathol Exp Neurol. 2016 Oct;75(10):925-935. PMID: 27539476.

Wood M, Rawe M, Johansson G, Pang S, Soderquist RS, Patel AV, Nelson S, Seibel W, Ratner N, Sanchez Y. "Discovery of a small molecule targeting IRA2 deletion in budding yeast and neurofibromin loss in malignant peripheral nerve sheath tumor cells." Mol Cancer Ther. 2011 Sep;10(9):1740-50. PMID: 21697395.

Wood MD, Sanchez Y. "Deregulated Ras signaling compromises DNA damage checkpoint recovery in S. cerevisiae." Cell Cycle. 2010 Aug 15;9(16):3353-63. PMID: 20716966.

Hayes J, Yu Y, Jalbert LE, Mazor T, Jones LE, Wood MD, Walsh KM, Bengtsson H, Hong C, Oberndorfer S, Roetzer T, Smirnov IV, Clarke JL, Aghi MK, Chang SM, Nelson SJ, Woehrer A, Phillips JJ, Solomon DA, Costello JF. "Genomic analysis of the origins and evolution of multicentric diffuse lower-grade gliomas." Neuro Oncol. 2017 Oct 25. PMID: 29077933.

Rutkowski MJ, Birk HS, Wood M, Perry A, Nicolaides T, Ames CP, Gupta N. "Metastatic clival chordoma: a case report of multiple extraneural metastases following resection and proton beam radiotherapy in a 5-year old boy." J Neurosurg Pediatr. 2017 May;19(5):531-537. PMID: 28304223.

Ohba S, Mukherjee J, Johannessen TC, Mancini A, Chow TT, Wood M, Jones L, Mazor T, Marshall RE, Viswanath P, Walsh KM, Perry A, Bell RJ, Phillips JJ, Costello JF, Ronen SM, Pieper RO. "Mutant IDH1 Expression Drives TERT Promoter Reactivation as Part of the Cellular Transformation Process." Cancer Res. 2016 Nov 15;76(22):6680-6689. PMID: 27758882.

Fontana MF, Baccarella A, Craft JF, Boyle MJ, McIntyre TI, Wood MD, Thorn KS, Anidi C, Bayat A, Chung MR, Hamburger R, Kim CY, Pearman E, Pham J, Tang JJ, Boon L, Kamya MR, Dorsey G, Feeney ME, Kim CC. "A Novel Model of Asymptomatic Plasmodium Parasitemia That Recapitulates Elements of the Human Immune Response to Chronic Infection." PLoS One. 2016;11(9):e0162132. PMID: 27583554;PMCID: PMC5008831.

Gospodarev V, Câmara J, Chakravarthy V, Perry A, Wood M, Dietz R, Wang J, De Los Reyes K, Raghavan R. "Treatment of IgG4-related pachymeningitis in a patient with steroid intolerance: The role of early use of rituximab." J Neuroimmunol. 2016 Oct 15;299:62-65. PMID: 27725123.

Allaway RJ, Fischer DA, de Abreu FB, Gardner TB, Gordon SR, Barth RJ, Colacchio TA, Wood M, Kacsoh BZ, Bouley SJ, Cui J, Hamilton J, Choi JA, Lange JT, Peterson JD, Padmanabhan V, Tomlinson CR, Tsongalis GJ, Suriawinata AA, Greene CS, Sanchez Y, Smith KD. "Genomic characterization of patient-derived xenograft models established from fine needle aspirate biopsies of a primary pancreatic ductal adenocarcinoma and from patient-matched metastatic sites." Oncotarget. 2016 Mar 29;7(13):17087-102. PMID: 26934555;PMCID: PMC4941373.

Schubert RD, Wood M, Levin MH, Perry A, Gelfand JM. "The severe side of the IgG4-related hypertrophic pachymeningitis disease spectrum." Neurol Neuroimmunol Neuroinflamm. 2016 Feb;3(1):e197. PMID: 26770998;PMCID: PMC4708924.

Solomon DA, Wood M, Tihan T, Bollen AW, Gupta N, Phillips JJ, Perry A. "Diffuse Midline Gliomas with Histone H3-K27M Mutation: A Series of 47 Cases Assessing the Spectrum of Morphologic Variation and Associated Genetic Alterations." Brain Pathol. 2016 Sep;26(5):569-80. PMID: 26517431.

Wilson MR, Shanbhag NM, Reid MJ, Singhal NS, Gelfand JM, Sample HA, Benkli B, O'Donovan B, Ali IK, Keating MK, Dunnebacke TH, Wood M, Bollen A, DeRisi JL. "Diagnosing Balamuthia mandrillaris Encephalitis With Metagenomic Deep Sequencing." Ann Neurol. 2015 Nov;78(5):722-30. PMID: 26290222;PMCID: PMC4624031 [Available on 11/01/16].

Bakhoum SF, Kabeche L, Wood MD, Laucius CD, Qu D, Laughney AM, Reynolds GE, Louie RJ, Phillips J, Chan DA, Zaki BI, Murnane JP, Petritsch C, Compton DA. "Numerical chromosomal instability mediates susceptibility to radiation treatment." Nat Commun. 2015 Jan 21;6:5990. PMID: 25606712;PMCID: PMC4516720.

Searle JS, Wood MD, Kaur M, Tobin DV, Sanchez Y. "Proteins in the nutrient-sensing and DNA damage checkpoint pathways cooperate to restrain mitotic progression following DNA damage." PLoS Genet. 2011 Jul;7(7):e1002176. doi: 10.1371/journal.pgen.1002176. Epub 2011 Jul 14. PMID 21779180.

Liby K, Royce DB, Risingsong R, Williams CR, Wood MD, Chandraratna RA, Sporn MB. "A new rexinoid, NRX194204, prevents carcinogenesis in both the lung and mammary gland." Clin Cancer Res. 2007 Oct 15;13(20):6237-43. PMID 17947492.

Aprelikova O, Chandramouli GV, Wood M, Vasselli JR, Riss J, Maranchie JK, et al. "Regulation of HIF prolyl hydroxylases by hypoxia-inducible factors." J Cell Biochem. 2004 Oct 15;92(3), 491-501. PMID 15156561.