Ongoing projects can be divided into the following different areas.

Neurobiology

Dr. Marjorie Grafe is studying CNS pathology in models of brain injury in rodents. Dr. Randy Woltjer is examining the effects of neurodegenerative diseases and myopathies in humans and in rodent models.

Hematologic Malignancies

Dr. Guang Fan is investigating the predictive and prognostic impacts of oncogenic mutations in cases of AML and pre-B ALL. Dr. Marc Loriaux has developed a novel screening method for assessing drug sensitivity in newly diagnosed cases of AML. Dr. Jennifer Dunlap is researching the feasibility of flow cytometry analysis to identify differences in lymphoma subtypes.

Dr. Rita Braziel continues to work with Nanostring to validate a gene expression profiling assay for diffuse large B-cell lymphomas, and is in the process of acquiring approval from the FDA for this assay. Dr. Rita Braziel continues to be the OHSU principal investigator for the Lymphoma/Leukemia Molecular Profiling Project (LLMPP), and is also collaborating on a project with the University of Washington to develop a new method of minimal residual disease detection after therapy for follicular lymphomas patients.

Solid Tumors

Dr. Christopher Corless has developed mass spectroscopy-based panels that are used for oncogene mutation screening across a variety of solid tumors and hematologic malignancies. Dr. Terry Morgan is studying novel markers for the diagnosis of HPV-related lesions of the cervix and oropharynx.