Treating Where it Hurts - Sexual Pain Study

Treating Where it Hurts Study Image

Pain with sex is a common problem experienced by women after menopause and the relationship of vulvar symptoms to sexual difficulties is well established. However, research into this problem is variable in its focus, and there are many gaps. Additionally, we know that women have an increased risk of bladder problems after menopause. We wish to study the bacteria in the vulva and vagina before and after therapy with estrogen when the entryway area is treated. This study hopes to determine the effectiveness of estrogen therapy focused on sexual dysfunction in postmenopausal women.


The purpose of this study is to learn about the use of a low-dose estrogen cream applied in a new way to the vaginal entryway for the treatment of moderate or severe pain during sexual intercourse in postmenopausal women.


 You may be eligible for this study if:
  • You are a woman between 40-70 years of age
  • You are in a stable heterosexual relationship
  • You have gone through menopause
  • You have experienced pain with intercourse for at least 6 months
  • You are willing to use a low-dose estrogen daily for 3 months


There is no cost to you or your insurance to participate in this study. There is no compensation for participating in this study however, patient who complete both biopsies in the optional sub-study will be compensated $100. 

Who do I contact for additional information?

To find out more information and to learn if you are qualified to participate, fill out the online form or call the Women’s Health Research Unit confidential recruitment line.

complete the online form

503 494-3666