Current Clinical Trials in Contraception and Birth Control

Do You Need Emergency Contraception
The purpose of this study is to assess how effective different doses of emergency contraception work at preventing pregnancy for women who weight more than 176 lbs. PI: Alison Edelman MD, MPH eIRB #18441

Emergency Contraception and BMI
The purpose of this study is to improve the effectiveness of orally-dosed emergency contraceptives for women of higher BMIs. eIRB: 16291 PI: Alison Edelman, MD MPH

Progestin Only Pill Study
The purpose of this study is to learn more about the effects on cervical mucus and ovulation of delaying or missing taking a progestin only birth control pill. PI: Alison Edelman, MD, MPH eIRB #18179

TelAbortion Study
The purpose of this study is to assess service provision of medical abortion through telemedicine. eIRB #15974 www.telemedstudy.org

The PEARL Study
Pharmacist Expanded Access to Reproductive Healthcare PI: Maria Rodriguez, MD, MPH IRB #16158

Vaginal Contraceptive Ring Study
The purpose of this study is to investigate how effective a new vaginal contraceptive ring is at preventing pregnancy. PI: Jeffrey Jensen MD, MPH eIRB #18041

VeraCept Copper IUD Study
The purpose of this study is to find out how effective an investigational non-hormonal copper IUD is at preventing pregnancy. PI: Jeffrey Jensen MD, MPH eIRB #18848

Current Clinical Trials in Urogynecology

Overactive Bladder Study
The purpose of this research study is to determine if the urinary microbiome affects overactive bladder syndrome (OAB). Currently, not much is known about the cause of OAB; this study seeks to determine if bacteria in the urinary tract play a role in OAB. Rahel Nardos, MD; eIRB # 10729

Current Clinical Trials in Pregnancy and Infertility

Chronic Hypertension and Pregnancy
This study is being done to evaluate what the best, and safest treatment for mild chronic hypertension during pregnancy is for both mother and baby. PI: Leonardo Pereira, MD, MCR eIRB #17011

Functional Imaging of the Human Placenta by MRI
The purpose of this study is to use magnetic resonance imaging (MRI) to measure blood flow to the placenta during pregnancy. Maternal blood carries the oxygen and nutrients that the baby needs to grow and develop. This blood goes to the placenta which controls the exchange of nutrients to the baby and removal of waste products from the baby. The ability to look at blood flow whilst a baby is still in the womb will help obstetricians to find women who have poor blood flow (known as placental insufficiency) during pregnancy. Finding these potential problems during pregnancy, rather than delivery, may allow medical staff to intervene and give the best possible outcome for the baby. eIRB #15196, PI: Antonio Frias, MD

Maternal Well-Being Study
We are interested in working with pregnant women to reduce mood symptoms and promote well-bring during pregnancy and postpartum PI: Kristen Mackiewicz Seghete, PhD eIRB #19004

Medical Optimization & Management of Pregnancies with overt Type 2 Diabetes (MOMPOD)
The purpose of this study is to learn about the safety and effectiveness of the study drug metformin when added to insulin treatment to help treat type 2 and early diagnosed diabetes in pregnancy. The study is trying to find out if metformin can be used safely in pregnancy to improve diabetes care and reduce problems at birth. PI: Amy Valent, DO eIRB #18438

Oxytocin Receptor DNA Methylation and Postpartum Maternal Outcomes
In this study we are trying to learn if genetics plays a role in why some women have too much bleeding after birth. We are also interested in knowing more about how women's physical and mental recovery goes in the first year after birth whether or not they have had too much bleeding and how it related to their genetics as well. PI: Elise Erickson, PhD, CNM eIRB #18841

Placenta Repository: A Study of Placental Function in Healthy and Pathological Pregnancies
Our long term goal is to identify pregnancies that are at risk of poor outcomes and to develop methods for prevention and treatment. eIRB # 16328; PI: Leonardo Pereira, MD

Prenatal Environment And Child Health (PEACH) Study
OHSU researchers are conducting a study that looks at how maternal diet and metabolic state during pregnancy might affect child brain development and behavior. You can help us by participating in our research. PI: Elinor Sullivan, PhD and Joel Nigg, PhD eIRB #18579

Roo Study on Mom and Baby Well-Being
We are looking for pregnant people who have experienced difficulties with low mood, anxiety or high stress levels. We hope to learn if mindfulness groups can promote well-being and self-care during pregnancy and support infant brain development. PI: Alice Graham, PhD eIRB #19166

Rosacea Course Fluctuations during Pregnancy: a Longitudinal Observational Study
The purpose of this study is to characterize the course of rosacea severity throughout pregnancy.<br />PI: Jon Hanifin, MD eIRB #16647

VentFirst: A multicenter RCT of assisted ventilation during delayed cord clamping for micro-preemies
The purpose of this study is to determine whether delaying clamping of the umbilical cord up to 120 seconds and assisting breathing for extremely premature babies during that time reduces intraventricular hemorrhage (bleeding in the brain). PI: Jamie B. Warren, MD, MPH eIRB#15777

Current Clinical Trials in Menopause

Overactive Bladder Study
The purpose of this research study is to determine if the urinary microbiome affects overactive bladder syndrome (OAB). Currently, not much is known about the cause of OAB; this study seeks to determine if bacteria in the urinary tract play a role in OAB. Rahel Nardos, MD; eIRB # 10729

Remote Mindfulness-Education for Women with Provoked Localized Vulvodynia
This is a study designed to learn more about the use of an online remote education and mindfulness practice program for the pain and anxiety associated with provoked localized vulvodynia. Participants will be randomized to one of two groups: online education seminars alone or mindfulness practice using the Headspace app in combination with the online education seminars. PI: Catherine Leclair, MD, eIRB #18191

Treating Where it Hurts - Sexual Pain Study
The purpose of this study is to learn about the use of a low-dose estrogen cream applied in a new way to the vaginal entryway for the treatment of moderate or severe pain during sexual intercourse in postmenopausal women. PI: Martha F. Goetsch MD, MPH eIRB# 16770

Clinical Trials in Heavy Menstrual Bleeding

Current Clinical Trials in other areas of women’s health

Biobehavioral Lactation Outcomes Following Oxytocin Administration During Parturition
The purpose of this study is to learn more about maternal hormone levels involved in lactation and their relationship to breastfeeding outcomes in women who received oxytocin as part of their birth experience compared to those who did not. Cathy L. Emeis, CNM, PhD, eIRB #15142

OHSU Employees' Opinions of Clinical Research
The goal of this study is to identify how employees feel regarding their participation in clinical research. PI: Jeffrey Jensen, MD, MPH eIRB #: 17248

Remote Mindfulness-Education for Women with Provoked Localized Vulvodynia
This is a study designed to learn more about the use of an online remote education and mindfulness practice program for the pain and anxiety associated with provoked localized vulvodynia. Participants will be randomized to one of two groups: online education seminars alone or mindfulness practice using the Headspace app in combination with the online education seminars. PI: Catherine Leclair, MD, eIRB #18191