Pioneering personalized medicine research in human gene correction, mitochondrial replacement therapy (MRT), human embryonic stem cells (hESC), induced pluripotent stem cells (iPS) & somatic cell nuclear transfer (SCNT) Support our Lab
In the News
Gene-Editing Technique in Human Embryos Draws Skepticism. The Wall Street Journal Critics challenge a study saying a disease-causing gene
mutation was repaired in human embryos
Profiles in precision medicine Advances in DNA testing and gene editing have given people choices that would have been impossible a few decades ago. Here, in their own words (including Dr. Paula Amato), are the stories of four people confronted with these dilemmas.
SCIENTISTS TAKE A HARDER LOOK AT GENETIC ENGINEERING OF HUMAN EMBRYOS. WIRED Genetic modification of human embryos is controversial for obvious reasons—and less obvious ones, like whether it really works.
Study verifies gene repair breakthrough. OHSU News. Research published in Nature confirms discovery of DNA repair mechanism
CBS's 60 Minutes included Shoukhrat Mitalipov and his groundbreaking work in their segment about CRISPR highlighting our efforts to use CRISPR to prevent disease by correcting genes in human embryos.
CBS's 60 Minutes Overtime included a segment with our physician collaborator, Dr. Paula Amato, whom discusses the ethical reasons of pursuing technologies that may be used to prevent disease in future generations.Mitalipov successfully repairs genes in human embryos
A ground breaking discovery by Shoukhrat Mitalipov, Ph.D., was reported in Nature —the successful removal of a lethal genetic defect in human embryos. The breakthrough is the initial confirmation that a dangerous genetic defect can in theory be erased.
Scientific success in embryo editing re-opens reg debate. BioWorld
In Breakthrough, Scientists Edit a Dangerous Mutation From Genes in Human Embryos. NY Times
Scientists Precisely Edit DNA In Human Embryos To Fix A Disease Gene. NPR
Human embryos edited to stop disease. BBC
A Gene Editing Breakthrough. On Point with Tom Ashbrook.
First U.S.-based group to edit human embryos brings practice closer to clinic. Science
In breakthrough, OHSU corrects defective gene in embryo. Oregonlive.
First Safe Repair of Gene in Human Embryos. Associated Press.
New research provides key insight about mitochondrial replacement therapy
A new discovery may unlock the answer to a vexing scientific question: How to conduct mitochondrial replacement therapy, a new gene-therapy technique, in such a way that safely prevents the transmission of harmful mitochondrial gene mutations from mothers to their children.
For women with mitochondrial diseases, a step closer to preventing transmission. STAT
Human embryo experiment shows progress toward 'three-parent' babies. The Washington Post
New Technique could increase success of infertility treatment
Families struggling with infertility or a genetic predisposition for debilitating mitochondrial diseases may someday benefit from a new breakthrough led by scientists at OHSU and the Salk Institute for Biological Studies.
Egg 'nobbles' can be used to create embryos, say scientists in fertility breakthrough
Fertility success may get boost from new research
Stat: In the Lab
First he pioneered a new way of making life. Now he wants to try it in people
365 days: Nature's 10
Shoukhrat Mitalipov: The cloning chief.
Human Cloning at Last: Science
Researchers announced they had derived stem cells from
cloned human embryos, a long-awaited research coup that Science's editors chose
as a runner-up for Breakthrough of the Year..
Read the article on Science
The Top Ten Medical Breakthroughs: Time
#4. Finally, We're Just Like Dolly
The Top Ten Science Stories of 2013: Discover
#5. Functioning Organs Made From Stem Cells
This Year's Biggest Discoveries in Science: National Geographic
#2. Human embryonic stem cells cloned